Repositioning Candidate Details
| Candidate ID: | R0219 |
| Source ID: | DB00753 |
| Source Type: | approved; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Isoflurane |
| Synonyms: | |
| Molecular Formula: | C3H2ClF5O |
| SMILES: | FC(F)OC(Cl)C(F)(F)F |
| Structure: |
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| DrugBank Description: | A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. |
| CAS Number: | 26675-46-7 |
| Molecular Weight: | 184.492 |
| DrugBank Indication: | For induction and maintenance of general anesthesia. |
| DrugBank Pharmacology: | Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. |
| DrugBank MoA: | Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca<sup>2+</sup> activated potassium channel, the glutamate receptor and the glycine receptor. |
| Targets: | Gamma-aminobutyric acid receptor subunit alpha-1; Calcium-transporting ATPase type 2C member 1; Glycine receptor subunit alpha-1; Glutamate receptor 1; Potassium voltage-gated channel subfamily A member 1; GABA-A receptor (anion channel); ATP synthase subunit delta, mitochondrial; Calmodulin; Neuronal acetylcholine receptor subunit alpha-4; Neuronal acetylcholine receptor subunit beta-2 |
| Inclusion Criteria: |
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