Therapeutic Targets
Therapeutic targets for CKD are manually extracted from research articles. For each target, reference researches are provided, and target details are derived from UniProt. Related drugs and repositioning candidates in CKDdb are presented with knowledge graphs.
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52 records.
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T02 | Alpha-2a adrenergic receptor | ADRA2A | Target is a single protein chain | P08913 | ADRA2A_HUMAN | Details | |
| T03 | Angiotensin-converting enzyme | ACE | INHIBITOR | Target is a single protein chain | P12821 | ACE_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor gamma | PPARG | AGONIST; MODULATOR; PARTIAL AGONIST; ANTAGONIST | Target is a single protein chain | P37231 | PPARG_HUMAN | Details |
| T05 | Glucagon receptor | GCGR | AGONIST; ANTAGONIST; INHIBITOR | Target is a single protein chain | P47871 | GCGR_HUMAN | Details |
| T06 | Sulfonylurea receptor 1 | ABCC8 | Target is a single protein chain | Q09428 | ABCC8_HUMAN | Details | |
| T07 | Potassium channel, inwardly rectifying, subfamily J, member 11 | KCNJ11 | OPENER | Target is a single protein chain | Q14654 | KCNJ11_HUMAN | Details |
| T08 | Alpha-galactosidase A | GLA | STABILISER | Hydrolase | P06280 | GLA_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T10 | Neutral alpha-glucosidase AB | GANAB | Hydrolase | Q14697 | GANAB_HUMAN | Details | |
| T11 | Hepatic lipase | LIPC | Hydrolase | P11150 | LIPC_HUMAN | Details | |
| T12 | Melatonin receptor 1B | MTNR1B | Target is a single protein chain | P49286 | MTNR1B_HUMAN | Details | |
| T13 | Renin | REN | INHIBITOR | Target is a single protein chain | P00797 | REN_HUMAN | Details |
| T14 | Integrin alpha-3 | ITGA3 | Target is a single protein chain | P26006 | ITGA3_HUMAN | Details | |
| T15 | Steryl-sulfatase | STS | INHIBITOR | Hydrolase | P08842 | STS_HUMAN | Details |
| T16 | Phospholipase C-gamma-2 | PLCG2 | Hydrolase | P16885 | PLCG2_HUMAN | Details | |
| T17 | Protein-tyrosine phosphatase 1B | PTPN1 | Target is a single protein chain | P18031 | PTPN1_HUMAN | Details | |
| T18 | Fibronectin | FN1 | PROTEOLYTIC ENZYME; OTHER; BINDING AGENT | Target is a single protein chain | P02751 | FN1_HUMAN | Details |
| T19 | Hexokinase type IV | GCK | ACTIVATOR | Target is a single protein chain | P35557 | GCK_HUMAN | Details |
| T20 | Hepatocyte nuclear factor 4-alpha | HNF4A | ACTIVATOR | Target is a single protein chain | P41235 | HNF4A_HUMAN | Details |