Repositioning Candidate Details
| Candidate ID: | R0229 |
| Source ID: | DB00809 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Tropicamide |
| Synonyms: | |
| Molecular Formula: | C17H20N2O2 |
| SMILES: | CCN(CC1=CC=NC=C1)C(=O)C(CO)C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | One of the muscarinic antagonists with pharmacologic action similar to atropine and used mainly as an ophthalmic parasympatholytic or mydriatic. [PubChem] |
| CAS Number: | 1508-75-4 |
| Molecular Weight: | 284.3529 |
| DrugBank Indication: | Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye. |
| DrugBank Pharmacology: | Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly. |
| DrugBank MoA: | Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle. |
| Targets: | Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M3 |
| Inclusion Criteria: |
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