Repositioning Candidate Details
| Candidate ID: | R0237 |
| Source ID: | DB00831 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Trifluoperazine |
| Synonyms: | |
| Molecular Formula: | C21H24F3N3S |
| SMILES: | CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 |
| Structure: |
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| DrugBank Description: | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. |
| CAS Number: | 117-89-5 |
| Molecular Weight: | 407.496 |
| DrugBank Indication: | For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation. |
| DrugBank Pharmacology: | Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. |
| DrugBank MoA: | Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. |
| Targets: | Dopamine D2 receptor; Neuron-specific vesicular protein calcyon; Alpha-1A adrenergic receptor; Calmodulin; Troponin C, slow skeletal and cardiac muscles; Protein S100-A4 |
| Inclusion Criteria: |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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