Repositioning Candidate Details
| Candidate ID: | R0321 |
| Source ID: | DB01080 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Vigabatrin |
| Synonyms: | |
| Molecular Formula: | C6H11NO2 |
| SMILES: | NC(CCC(O)=O)C=C |
| Structure: |
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| DrugBank Description: | An analogue of gamma-aminobutyric acid, vigabatrin is an irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid. (From Martindale The Extra Pharmacopoeia, 31st ed). Off-label uses include treatment of cocaine dependence. |
| CAS Number: | 68506-86-5 |
| Molecular Weight: | 129.157 |
| DrugBank Indication: | For use as an adjunct in treatment resistant epilepsy, refractory complex partial seizures, and secondary generalized seizures. It is also used as monotherapy in infantile spasms in West syndrome. |
| DrugBank Pharmacology: | Vigabatrin is an anticonvulsant chemically unrelated to other anticonvulsants. Vigabatrin prevents the catabolism of GABA by irreversibly inhibiting the enzyme GABA transaminase. It is an analog of GABA, but it is not a receptor agonist. However, vigabatrin is not a potent inhibitor of GABA-T with a Ki of 10 mM. |
| DrugBank MoA: | Vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase, GABA-T). Duration of action is determined by rate of GABA-T re-synthesis. Vigabatrin may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Although administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active. |
| Targets: | 4-aminobutyrate aminotransferase, mitochondrial |
| Inclusion Criteria: |
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