Repositioning Candidate Details
| Candidate ID: | R0338 |
| Source ID: | DB01137 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Levofloxacin |
| Synonyms: | |
| Molecular Formula: | C18H20FN3O4 |
| SMILES: | C[C@H]1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1 |
| Structure: |
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| DrugBank Description: | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. |
| CAS Number: | 100986-85-4 |
| Molecular Weight: | 361.3675 |
| DrugBank Indication: | For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium</i> species, <i>Staphylococus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Streptococcus pneumoniae</i>, <i>Streptococcus</i> (Groups C/F/G), Viridans group streptococci, <i>Acinetobacter lwoffii</i>, <i>Haemophilus influenzae</i>, <i>Serratia marcescens</i>. |
| DrugBank Pharmacology: | Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of <i>Streptococcus pneumoniae</i>, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. |
| DrugBank MoA: | Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited. |
| Targets: | DNA gyrase subunit A; DNA topoisomerase 4 subunit A |
| Inclusion Criteria: |
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