Repositioning Candidate Details
| Candidate ID: | R0345 |
| Source ID: | DB01178 |
| Source Type: | approved; investigational; withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Chlormezanone |
| Synonyms: | |
| Molecular Formula: | C11H12ClNO3S |
| SMILES: | CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O |
| Structure: |
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| DrugBank Description: | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. |
| CAS Number: | 80-77-3 |
| Molecular Weight: | 273.736 |
| DrugBank Indication: | Used in the management of anxiety and in the treatment of muscle spasm. |
| DrugBank Pharmacology: | Chlormezanone is a non-benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis). |
| DrugBank MoA: | Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. |
| Targets: | Translocator protein |
| Inclusion Criteria: |
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