Repositioning Candidate Details
| Candidate ID: | R0376 |
| Source ID: | DB01339 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Vecuronium |
| Synonyms: | |
| Molecular Formula: | C34H57N2O4 |
| SMILES: | [H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](OC(C)=O)[C@H](C[C@]12C)N1CCCCC1)[N+]1(C)CCCCC1 |
| Structure: |
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| DrugBank Description: | Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. |
| CAS Number: | 86029-43-8 |
| Molecular Weight: | 557.8274 |
| DrugBank Indication: | Vecuronium is a muscle relaxing agent and is used as an adjunct in general anesthesia. |
| DrugBank Pharmacology: | The principal pharmacologic effects demonstrated by vecuronium revolve around its competitive binding of cholinergic receptors located at motor end plates. This competitive binding results in muscle relaxant effects that are typically employed as an adjunct to general anesthesia. |
| DrugBank MoA: | Vecuronium is a bisquaternary nitrogen compound that acts by competitively binding to nicotinic cholinergic receptors. The binding of vecuronium decreases the opportunity for acetylcholine to bind to the nicotinic receptor at the postjunctional membrane of the myoneural junction. As a result, depolarization is prevented, calcium ions are not released and muscle contraction does not occur. |
| Targets: | Neuronal acetylcholine receptor subunit alpha-2 |
| Inclusion Criteria: |
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