Repositioning Candidate Details
| Candidate ID: | R0384 |
| Source ID: | DB01403 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Methotrimeprazine |
| Synonyms: | |
| Molecular Formula: | C19H24N2OS |
| SMILES: | COC1=CC2=C(SC3=C(C=CC=C3)N2C[C@H](C)CN(C)C)C=C1 |
| Structure: |
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| DrugBank Description: | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) |
| CAS Number: | 60-99-1 |
| Molecular Weight: | 328.472 |
| DrugBank Indication: | For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. |
| DrugBank Pharmacology: | Methotrimeprazine is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) |
| DrugBank MoA: | Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role. |
| Targets: | Dopamine D2 receptor; Dopamine D1 receptor; Dopamine D5 receptor; Dopamine D3 receptor; Dopamine D4 receptor; 5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2C; Histamine H1 receptor; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M5; Alpha-1A adrenergic receptor; Alpha-1B adrenergic receptor; Alpha-1D adrenergic receptor; Alpha-2A adrenergic receptor; Alpha-2B adrenergic receptor; Alpha-2C adrenergic receptor |
| Inclusion Criteria: |
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