Repositioning Candidate Details
| Candidate ID: | R0209 |
| Source ID: | DB00722 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Lisinopril |
| Synonyms: | |
| Molecular Formula: | C21H31N3O5 |
| SMILES: | NCCCC[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |
| Structure: |
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| DrugBank Description: | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs.[A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.[A184844] Lisinopril was granted FDA approval on 29 December 1987.[L8384] |
| CAS Number: | 76547-98-3 |
| Molecular Weight: | 405.4879 |
| DrugBank Indication: | Lisinopril is indicated for the treatment of acute myocardial infarction, hypertension in patients ≥6 years, and as an adjunct therapy for heart failure.[L8384,L8387] A combination product with hydrochlorothiazide is indicated for the treatment of hypertension.[L8390] |
| DrugBank Pharmacology: | Lisinopril is an angiotensin converting enzyme inhibitor used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril is not a prodrug, and functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] It has a wide therapeutic index and a long duration of action as patients are generally given 10-80mg daily.[L8384,L8387,L8390] |
| DrugBank MoA: | Angiotensin II constricts coronary blood vessels and is positively inotropic, which under normal circumstances, would increase vascular resistance and oxygen consumption.[A184781] This action can eventually lead to myocyte hypertrophy and vascular smooth muscle cell proliferation.[A184781] Lisinopril is an angiotensin converting enzyme inhibitor (ACEI), preventing the conversion of angiotensin I to angiotensin II.[A184781,A184808] This action prevents myocyte hypertrophy and vascular smooth muscle cell proliferation seen in untreated patients.[A184808] Increased levels of bradykinin also exhibit vasodilating effects for patients taking ACEIs.[A184808] Lisinopril also inhibits renin's conversion of angiotensin to angiotensin I.[A184817] |
| Targets: | Angiotensin-converting enzyme; Renin |
| Inclusion Criteria: |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details |