Repositioning Candidate Details
| Candidate ID: | R0220 |
| Source ID: | DB00758 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Clopidogrel |
| Synonyms: | |
| Molecular Formula: | C16H16ClNO2S |
| SMILES: | [H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl |
| Structure: |
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| DrugBank Description: | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213] |
| CAS Number: | 113665-84-2 |
| Molecular Weight: | 321.822 |
| DrugBank Indication: | Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] |
| DrugBank Pharmacology: | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] It has a long duration of action as it is taken once daily and a large therapeutic window as it is given in doses of 75-300mg daily.[L7213] |
| DrugBank MoA: | Clopidogrel is metabolized to its active form by carboxylesterase-1.[A180508] The active form is a platelet inhibitor that irreversibly binds to P2Y<sub>12</sub> ADP receptors on platelets.[L7213] This binding prevents ADP binding to P2Y<sub>12</sub> receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet aggregation.[L7213] |
| Targets: | P2Y purinoceptor 12 |
| Inclusion Criteria: |
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