Repositioning Candidate Details
| Candidate ID: | R0245 |
| Source ID: | DB00852 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Pseudoephedrine |
| Synonyms: | |
| Molecular Formula: | C10H15NO |
| SMILES: | CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889.[A188823] The decongestant effect of pseudoephedrine was described in dogs in 1927.[A188823] |
| CAS Number: | 90-82-4 |
| Molecular Weight: | 165.2322 |
| DrugBank Indication: | For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism. |
| DrugBank Pharmacology: | Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa). |
| DrugBank MoA: | Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors. |
| Targets: | Sodium-dependent noradrenaline transporter; Sodium-dependent dopamine transporter; Alpha-1A adrenergic receptor; Alpha-2A adrenergic receptor; Sodium-dependent serotonin transporter; Beta-2 adrenergic receptor; Beta-1 adrenergic receptor; Nuclear factor of activated T-cells, cytoplasmic 1; Tumor necrosis factor; Nuclear factor NF-kappa-B p105 subunit; activator protein 1; Interleukin-2 |
| Inclusion Criteria: |
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