Repositioning Candidate Details
| Candidate ID: | R0271 |
| Source ID: | DB00935 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Oxymetazoline |
| Synonyms: | |
| Molecular Formula: | C16H24N2O |
| SMILES: | CC1=CC(=C(O)C(C)=C1CC1=NCCN1)C(C)(C)C |
| Structure: |
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| DrugBank Description: | A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251) |
| CAS Number: | 1491-59-4 |
| Molecular Weight: | 260.3746 |
| DrugBank Indication: | For treatment of nasal congestion and redness associated with minor irritations of the eye |
| DrugBank Pharmacology: | Oxymetazoline a adrenergic alpha-agonists, direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug's action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis. |
| DrugBank MoA: | Oxymetazoline is a direct acting sympathomimetic amine, which acts on alpha-adrenergic receptors in the arterioles of the conjunctiva and nasal mucosa. It produces vasoconstriction, resulting in decreased conjunctival congestion in ophthalmic. In nasal it produces constriction, resulting in decreased blood flow and decreased nasal congestion. |
| Targets: | Alpha-1A adrenergic receptor; Alpha-2A adrenergic receptor; Alpha-2B adrenergic receptor; Alpha-2C adrenergic receptor; Alpha-1B adrenergic receptor; Alpha-1D adrenergic receptor; 5-hydroxytryptamine receptor 1A; 5-hydroxytryptamine receptor 1B; 5-hydroxytryptamine receptor 1D; 5-hydroxytryptamine receptor 1C |
| Inclusion Criteria: |
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