Repositioning Candidate Details
| Candidate ID: | R0277 |
| Source ID: | DB00957 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Norgestimate |
| Synonyms: | |
| Molecular Formula: | C23H31NO3 |
| SMILES: | [H][C@@]12CC[C@@](OC(C)=O)(C#C)[C@@]1(CC)CC[C@]1([H])[C@@]3([H])CC\C(C=C3CC[C@@]21[H])=N/O |
| Structure: |
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| DrugBank Description: | Norgestimate is a form of progesterone, which is a female hormone important for the regulation of ovulation and menstruation. Norgestimate is used with estradiol to treat the symptoms of menopause. |
| CAS Number: | 35189-28-7 |
| Molecular Weight: | 369.4971 |
| DrugBank Indication: | For the prevention of pregnancy |
| DrugBank Pharmacology: | Norgestimate is used as a female contraceptive. Norgestimate is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Norgestimate tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries. |
| DrugBank MoA: | Norgestimate binds to androgen and progestogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Norgestimate will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. |
| Targets: | Progesterone receptor; Estrogen receptor alpha; Androgen receptor |
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