Repositioning Candidate Details
| Candidate ID: | R0279 |
| Source ID: | DB00961 |
| Source Type: | approved; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Mepivacaine |
| Synonyms: | |
| Molecular Formula: | C15H22N2O |
| SMILES: | CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C |
| Structure: |
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| DrugBank Description: | A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168) |
| CAS Number: | 96-88-8 |
| Molecular Weight: | 246.348 |
| DrugBank Indication: | For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks. |
| DrugBank Pharmacology: | Mepivicaine is an amide local anesthetic. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal. |
| DrugBank MoA: | Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone. |
| Targets: | Sodium channel protein type 10 subunit alpha |
| Inclusion Criteria: |
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