Repositioning Candidate Details
| Candidate ID: | R0280 |
| Source ID: | DB00962 |
| Source Type: | approved; illicit; investigational |
| Compound Type: | small molecule |
| Compound Name: | Zaleplon |
| Synonyms: | |
| Molecular Formula: | C17H15N5O |
| SMILES: | CCN(C(C)=O)C1=CC=CC(=C1)C1=CC=NC2=C(C=NN12)C#N |
| Structure: |
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| DrugBank Description: | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. |
| CAS Number: | 151319-34-5 |
| Molecular Weight: | 305.3339 |
| DrugBank Indication: | For the treatment of short-term treatment of insomnia in adults. |
| DrugBank Pharmacology: | Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia. While Zaleplon is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABA<sub>B</sub>Z) receptor complex. Subunit modulation of the GABA<sub>B</sub>Z receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models. Zaleplon also binds selectively to the CNS GABA<sub>A</sub>-receptor chloride ionophore complex at benzodiazepine(BZ) omega-1 (BZ1, ο1) receptors. |
| DrugBank MoA: | Zaleplon exerts its action through subunit modulation of the GABA<sub>B</sub>Z receptor chloride channel macromolecular complex. Zaleplon also binds selectively to the brain omega-1 receptor located on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding. |
| Targets: | Gamma-aminobutyric acid receptor subunit alpha-1 |
| Inclusion Criteria: |
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