Repositioning Candidate Details
| Candidate ID: | R0318 |
| Source ID: | DB01069 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Promethazine |
| Synonyms: | |
| Molecular Formula: | C17H20N2S |
| SMILES: | CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)N(C)C |
| Structure: |
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| DrugBank Description: | A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. |
| CAS Number: | 60-87-7 |
| Molecular Weight: | 284.419 |
| DrugBank Indication: | For the treatment of allergic disorders, and nausea/vomiting. |
| DrugBank Pharmacology: | Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness. |
| DrugBank MoA: | Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone. |
| Targets: | Histamine H1 receptor; Dopamine D2 receptor; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M5; Alpha adrenergic receptor; Calmodulin; Histamine H2 receptor; NA; Voltage-gated sodium channel alpha subunit; NA |
| Inclusion Criteria: |
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