Repositioning Candidate Details
| Candidate ID: | R0327 |
| Source ID: | DB01100 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Pimozide |
| Synonyms: | |
| Molecular Formula: | C28H29F2N3O |
| SMILES: | FC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1 |
| Structure: |
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| DrugBank Description: | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403) |
| CAS Number: | 2062-78-4 |
| Molecular Weight: | 461.5462 |
| DrugBank Indication: | Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment. |
| DrugBank Pharmacology: | Pimozide is an orally active antipsychotic drug product which shares with other antipsychotics the ability to blockade dopaminergic receptors on neurons in the central nervous system. However, receptor blockade is often accompanied by a series of secondary alterations in central dopamine metabolism and function which may contribute to both pimozide's therapeutic and untoward effects. In addition, pimozide, in common with other antipsychotic drugs, has various effects on other central nervous system receptor systems which are not fully characterized. Pimozide also has less potential for inducing sedation and hypotension as it has more specific dopamine receptor blocking activity than other neuroleptic agents (and is therefore a suitable alternative to haloperidol). |
| DrugBank MoA: | The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds and inhibits the dopamine D2 receptor in the CNS. |
| Targets: | Dopamine D2 receptor; Dopamine D3 receptor; Potassium voltage-gated channel subfamily H member 2; Calmodulin |
| Inclusion Criteria: |
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