Repositioning Candidate Details
| Candidate ID: | R0041 |
| Source ID: | DB00172 |
| Source Type: | nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Proline |
| Synonyms: | |
| Molecular Formula: | C5H9NO2 |
| SMILES: | OC(=O)[C@@H]1CCCN1 |
| Structure: |
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| DrugBank Description: | Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. |
| CAS Number: | 147-85-3 |
| Molecular Weight: | 115.1305 |
| DrugBank Indication: | L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles. |
| DrugBank Pharmacology: | L-Proline is a major amino acid found in cartilage and is important for maintaining youthful skin as well as repair of muscle, connective tissue and skin damage. It is also essential for the immune system, and for necessary balance of this formula. It is an essential component of collagen and is important for proper functioning of joints and tendons. L-Proline is extremely important for the proper functioning of joints and tendons. Helps maintain and strengthen heart muscles. |
| DrugBank MoA: | Glycogenic, by L-Proline oxidase in the kidney, it is ring-opened and is oxidized to form L-Glutamic acid. L-Ornithine and L-Glutamic acid are converted to L-Proline via L-Glutamic acid-gamma-semialdehyde. It is contained abundantly in collagen, and is intimately involved in the function of arthrosis and chordae. |
| Targets: | Pyrroline-5-carboxylate reductase 1, mitochondrial; Bifunctional glutamate/proline--tRNA ligase; Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); Sodium-dependent proline transporter; Pyrroline-5-carboxylate reductase 2; Prolyl 4-hydroxylase subunit alpha-2; Proline dehydrogenase 1, mitochondrial; Peptidyl-prolyl cis-trans isomerase H; Proline synthase co-transcribed bacterial homolog protein; Prolyl 4-hydroxylase subunit alpha-1; Peptidyl-prolyl cis-trans isomerase B; Peptidyl-prolyl cis-trans isomerase F, mitochondrial; Peptidyl-prolyl cis-trans isomerase C; Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase G; Prolyl 3-hydroxylase 1; Pyrroline-5-carboxylate reductase; Probable proline--tRNA ligase, mitochondrial; Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase 3; Pyrroline-5-carboxylate reductase 3; Trans-L-3-hydroxyproline dehydratase |
| Inclusion Criteria: |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details |