Repositioning Candidate Details
| Candidate ID: | R0428 |
| Source ID: | DB04842 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Fluspirilene |
| Synonyms: | |
| Molecular Formula: | C29H31F2N3O |
| SMILES: | FC1=CC=C(C=C1)C(CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1)C1=CC=C(F)C=C1 |
| Structure: |
|
| DrugBank Description: | A long-acting injectable antipsychotic agent used for chronic schizophrenia. |
| CAS Number: | 1841-19-6 |
| Molecular Weight: | 475.5727 |
| DrugBank Indication: | Used for the treatment of schizophrenia. |
| DrugBank Pharmacology: | Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia. Fluspirilene does not differ greatly from other depot antipsychotics (fluphenazine decanoate, fluphenazine enathate, perphenazine onanthat, pipotiazine undecylenate) with respect to treatment efficacy, response or tolerability. Outcomes suggest that fluspirilene does not differ significantly from oral antipsychotics or in different weekly regimens, although much cannot be inferred because of the shortage of trials. |
| DrugBank MoA: | |
| Targets: | Dopamine D2 receptor; 5-hydroxytryptamine receptor 2A; Voltage-dependent calcium channel gamma-1 subunit |
| Inclusion Criteria: |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|