Repositioning Candidate Details
| Candidate ID: | R0438 |
| Source ID: | DB05667 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Levoketoconazole |
| Synonyms: | |
| Molecular Formula: | C26H28Cl2N4O4 |
| SMILES: | CC(=O)N1CCN(CC1)C1=CC=C(OC[C@@H]2CO[C@](CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1 |
| Structure: |
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| DrugBank Description: | Levoketoconazole is a cortisol synthesis inhibitor that is being developed as a therapy for glucose and cholesterol control in patients with type 2 diabetes mellitus. |
| CAS Number: | 142128-57-2 |
| Molecular Weight: | 531.431 |
| DrugBank Indication: | Investigated for use/treatment in diabetes mellitus type 2. |
| DrugBank Pharmacology: | |
| DrugBank MoA: | Preliminary data suggests that DIO-902 increases insulin sensitivity by lowering cortisol levels. The primary mechanism of action is via inhibition of the 11-β-hydroxylase enzyme, the terminal step in cortisol synthesis in the adrenal gland. DIO-902 has also been shown to lower total and LDL-cholesterol by inhibiting 14-α-demethylase, a key enzyme in cholesterol synthesis. In combination with a typical glucose-lowering agent, such as metformin, DIO-902 may enhance glucose control and improve total and LDL-cholesterol. [DiObex Press Release] |
| Targets: | Steroid 17-alpha-hydroxylase/17,20 lyase; Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B2, mitochondrial; Cholesterol side-chain cleavage enzyme, mitochondrial; Lanosterol 14-alpha demethylase |
| Inclusion Criteria: |
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