Repositioning Candidate Details
| Candidate ID: | R0468 |
| Source ID: | DB08439 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Parecoxib |
| Synonyms: | |
| Molecular Formula: | C19H18N2O4S |
| SMILES: | CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C1=C(C)ON=C1C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005. |
| CAS Number: | 198470-84-7 |
| Molecular Weight: | 370.422 |
| DrugBank Indication: | Used for short term perioperative pain control. |
| DrugBank Pharmacology: | |
| DrugBank MoA: | |
| Targets: | Prostaglandin G/H synthase 2; Lactotransferrin |
| Inclusion Criteria: |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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