Repositioning Candidate Details
| Candidate ID: | R0481 |
| Source ID: | DB09020 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Bisacodyl |
| Synonyms: | |
| Molecular Formula: | C22H19NO4 |
| SMILES: | CC(=O)OC1=CC=C(C=C1)C(C1=CC=C(OC(C)=O)C=C1)C1=CC=CC=N1 |
| Structure: |
|
| DrugBank Description: | Bisacodyl is an organic stimulant laxative that acts directly on the colon to promote bowel movement. Bisacodyl is prescribed for constipation, neurogenic bowel dysfunction, and bowel preparation before medical examinations. |
| CAS Number: | 603-50-9 |
| Molecular Weight: | 361.3906 |
| DrugBank Indication: | Indicated for cleansing of the colon as a preparation for colonoscopy in adults. |
| DrugBank Pharmacology: | Bisacodyl is hydrolyzed by intestinal brush border enzymes and colonic bacteria to form an active metabolite [bis-(p-hydroxyphenyl) pyridyl-2 methane; (BHPM)] that acts directly on the colonic mucosa to produce colonic peristalsis. |
| DrugBank MoA: | Induces diarrhea which cleanses the colon. |
| Targets: | Aquaporin-3; NA |
| Inclusion Criteria: |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|