Repositioning Candidate Details
| Candidate ID: | R0487 |
| Source ID: | DB09096 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Benzoyl peroxide |
| Synonyms: | |
| Molecular Formula: | C14H10O4 |
| SMILES: | O=C(OOC(=O)C1=CC=CC=C1)C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Benzoyl peroxide (BPO) is an organic compound in the peroxide family. It is formed by two benzoyl groups which are connected by a peroxide link. It is one of the most important organic peroxides in terms of applications. In medicine, benzoyl peroxide is used as a topical treatment for acne, either in combination with antibiotics or as a single agent. These products are available over-the-counter or by prescription in gels, creams or liquids at concentrations of 2.5%, 5% or 10%. Benzoyl peroxide is also used for bleaching flour or hair, teeth whitening, for cross-linking polyester resins, and many other chemical uses. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. |
| CAS Number: | 94-36-0 |
| Molecular Weight: | 242.2268 |
| DrugBank Indication: | Benzoyl peroxide is indicated for the treatment of mild to moderate acne vulgaris and rosacea. Combined with other agents, it may be used in the treatment of more severe acne. |
| DrugBank Pharmacology: | Benzoyl peroxide acts as an antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory agent when applied topically to the human epithelium. |
| DrugBank MoA: | Benzoyl peroxide decomposes to release oxygen after topical application. This oxygen acts as a bactericidal agent towards Proprionibacterium acnes, the bacteria present in acne vulgaris. Benzoyl peroxide also increases the turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of comedones. |
| Targets: | Catalase; NA; Arginine decarboxylase; Protein kinase C; NA |
| Inclusion Criteria: |
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