Repositioning Candidate Details
| Candidate ID: | R0498 |
| Source ID: | DB11091 |
| Source Type: | approved; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Hydrogen peroxide |
| Synonyms: | |
| Molecular Formula: | H2O2 |
| SMILES: | OO |
| Structure: |
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| DrugBank Description: | Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it may undergo potentially explosive thermal decomposition. Hydrogen peroxide is formed in the body of mammals during reduction of oxygen either directly in a two-electron transfer reaction [L2024]. As a natural product of metabolism, it readily undergoes decomposition by catalase in normal cells [L2024]. Due to its potent and broad-spectrum antimicrobial actions, hydrogen peroxide is used in both liquid and gas form for preservative, disinfection and sterilization applications as an oxidative biocide [A32369]. It is used in industrial and cosmetic applications as a bleaching agent. Hydrogen peroxide is also considered as a generally recognized as safe compound by the FDA [L2024]; it is used as an antimicrobial agent in starch and cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg whites, and dried egg yolks. |
| CAS Number: | 7722-84-1 |
| Molecular Weight: | 34.0147 |
| DrugBank Indication: | Indicated to be used as a disinfectant and sterilizer. |
| DrugBank Pharmacology: | Hydrogen peroxide exhibits antimicrobial properties against most forms of microorganisms, including dormant forms with known high resistance profiles, such as bacterial spores and protozoal cysts. It acts as an oxidative biocide to generate free radical species to induce DNA, protein and membrane lipid damage via oxidation. |
| DrugBank MoA: | The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide. Free radicals eventually lead to oxidative damage proteins and membrane lipids _in vivo_ [A32371]. The oxidizing radical as the ferryl radical induces DNA oxidation [A32371]. |
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