CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of CKD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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FXR9 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C01164 | BRD-K18135438 | chenodeoxycholic-acid | HSD11B1|NR1H4 | 11-beta hydroxysteroid dehydrogenase inhibitor; FXR agonist | Details | |
| C02137 | BRD-K08864679 | fexaramine | NR1H4 | FXR agonist | Details | |
| C02402 | BRD-K26674531 | GR-235 | NR1H4 | estrogen receptor agonist; FXR antagonist; progesterone receptor agonist | Details | |
| C02482 | BRD-K88186167 | GW-4064 | NR1H4 | FXR agonist | Details | |
| C02723 | BRD-K30968378 | INT-747 | FXR agonist | Details | ||
| C02724 | BRD-K33067152 | INT-767 | GPBAR1 | FXR agonist | Details | |
| C03085 | BRD-K04497194 | lithocholic-acid | GPBAR1|NR1H4|NR1I2|VDR | FXR antagonist; vitamin D receptor agonist | Details | |
| C03842 | BRD-A75838038 | obeticholic-acid | NR1H4 | FXR agonist | Details | |
| C05806 | BRD-K54640016 | WAY-362450 | NR1H4 | FXR agonist | Details |