CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01023
Pert ID:	BRD-A10977446
Compound Name:	carvedilol
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|ADRB1\|ADRB2\|ADRB3\|GJA1\|HIF1A\|KCNH2\|NDUFC2\|NPPB\|SELE\|VCAM1\|VEGFA
MoA:	adrenergic receptor antagonist
SMILES:	COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5496	BRD-A10977446	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24980	BRD-A10977446	MCF??7.00	10 uM	24 h	0.33	1.39	1.01	0.28	0.99	0.41
25277	BRD-A10977446	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37441	BRD-A10977446	ASC	10 uM	24 h	-0.21	-0.88	0.03	0.0	0.0	0.0
37783	BRD-A10977446	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37980	BRD-A10977446	HT29	10 uM	6 h	0.0	0.0	0.0	0.35	1.23	1.24
38819	BRD-A10977446	SKB	10 uM	24 h	0.19	0.79	0.0	0.0	0.0	0.0
52230	BRD-A10977446	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
87987	BRD-A10977446	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90925	BRD-A10977446	HUH7	8 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
121167	BRD-A10977446	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121203	BRD-A10977446	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121238	BRD-A10977446	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121272	BRD-A10977446	HELA	10 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
129388	BRD-A10977446	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.22	0.78	0.07

Summary