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CMap Candidate Details

Structure:
CMap ID: C01059
Pert ID: BRD-K87932577
Compound Name: CDK1-5-inhibitor
Targets: CDK1|CDK5|GSK3B
MoA: CDK inhibitor; glycogen synthase kinase inhibitor
SMILES: Nc1n[nH]c2nc3ccccc3nc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1653 BRD-K87932577 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2136 BRD-K87932577 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.2 1.18
2154 BRD-K87932577 PC3 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.02
2456 BRD-K87932577 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41853 BRD-K87932577 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42153 BRD-K87932577 A549 10 uM 6 h -0.25 -1.02 0.18 0.33 1.16 0.9
42490 BRD-K87932577 ASC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
42801 BRD-K87932577 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.22 1.25
43091 BRD-K87932577 HT29 10 uM 6 h 0.35 1.45 1.12 -0.23 -0.79 0.1
43361 BRD-K87932577 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43666 BRD-K87932577 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43966 BRD-K87932577 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44217 BRD-K87932577 SKB 10 uM 24 h 0.22 0.93 0.04 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).