CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01157
Pert ID:	BRD-K49049886
Compound Name:	CGS-15943
Targets:	ADORA1\|ADORA2A\|ADORA2B\|ADORA3
MoA:	adenosine receptor antagonist
SMILES:	Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1173	BRD-K49049886	PC3	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.34	1.85
1257	BRD-K49049886	A549	10 uM	48 h	0.0	0.0	0.0	-0.38	-1.27	1.39
1402	BRD-K49049886	U2OS	10 uM	6 h	0.0	0.0	0.0	-0.39	-1.32	1.71
6765	BRD-K49049886	A375	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.96	0.42
7332	BRD-K49049886	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
7671	BRD-K49049886	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.96	0.42
7876	BRD-K49049886	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
8134	BRD-K49049886	MCF??7.00	10 uM	6 h	0.27	1.11	0.25	-0.33	-1.11	0.91
25377	BRD-K49049886	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
53457	BRD-K49049886	HEPG2	2.5 uM	6 h	0.23	0.98	0.08	-0.27	-0.92	0.33
53516	BRD-K49049886	HUH7	2.5 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
53671	BRD-K49049886	PHH	10 uM	24 h	-0.23	-0.95	0.09	0.0	0.0	0.0
97465	BRD-K49049886	NKDBA	20 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary