CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01158
Pert ID:	BRD-K68103045
Compound Name:	CGS-20625
Targets:	GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6
MoA:	benzodiazepine receptor agonist; GABA benzodiazepine site receptor partial agonist
SMILES:	COc1ccc(cc1)-n1nc2c3CCCCCc3[nH]cc2c1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4467	BRD-K68103045	HCC515	10 uM	24 h	0.0	0.0	0.0	0.32	1.15	0.88
5113	BRD-K68103045	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39746	BRD-K68103045	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40851	BRD-K68103045	NEU	10 uM	24 h	-0.26	-1.1	0.34	0.0	0.0	0.0
41163	BRD-K68103045	NPC	10 uM	24 h	0.29	1.2	0.42	0.0	0.0	0.0
41501	BRD-K68103045	SKB	10 uM	24 h	0.24	1.0	0.11	0.0	0.0	0.0
126416	BRD-K68103045	HEK293	10 uM	24 h	-0.24	-0.99	0.14	0.27	0.94	0.29
126465	BRD-K68103045	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126488	BRD-K68103045	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126507	BRD-K68103045	MCF10A	0.37 uM	24 h	-0.34	-1.42	1.43	-0.25	-0.85	0.2
126530	BRD-K68103045	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126589	BRD-K68103045	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134337	BRD-K68103045	A375	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134367	BRD-K68103045	A549	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134388	BRD-K68103045	HA1E	0.03 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.15
134483	BRD-K68103045	HUVEC	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134584	BRD-K68103045	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134616	BRD-K68103045	PC3	0.08 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.19

Summary