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CMap Candidate Details

Structure:
CMap ID: C01164
Pert ID: BRD-K18135438
Compound Name: chenodeoxycholic-acid
Targets: HSD11B1|NR1H4
MoA: 11-beta hydroxysteroid dehydrogenase inhibitor; FXR agonist
SMILES: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33786 BRD-K18135438 A549 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.19
34326 BRD-K18135438 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34573 BRD-K18135438 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.91 0.3
34843 BRD-K18135438 HEPG2 10 uM 6 h 0.22 0.9 0.02 0.29 1.03 0.51
35107 BRD-K18135438 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35415 BRD-K18135438 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36064 BRD-K18135438 PC3 10 uM 6 h 0.0 0.0 0.0 0.36 1.27 1.34
36216 BRD-K18135438 PHH 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.05
36510 BRD-K18135438 SKB 10 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.85
36786 BRD-K18135438 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98796 BRD-K18135438 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98870 BRD-K18135438 NEU 10 uM 24 h -0.25 -1.05 0.23 -0.27 -0.91 0.31
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).