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CMap Candidate Details

Structure:
CMap ID: C01171
Pert ID: BRD-K16189898
Compound Name: CHIR-99021
Targets: CDK1|GSK3A|GSK3B|MAPK1
MoA: glycogen synthase kinase inhibitor
SMILES: Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1430 BRD-K16189898 NPC 10 uM 24 h 0.28 1.19 0.41 0.0 0.0 0.0
91839 BRD-K16189898 MCF10A 10 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
91868 BRD-K16189898 MCF??7.00 10 uM 24 h 0.36 1.51 1.44 0.0 0.0 0.0
91958 BRD-K16189898 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92448 BRD-K16189898 A549 1.11 uM 24 h -0.25 -1.04 0.21 -0.23 -0.78 0.1
92485 BRD-K16189898 BT20 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92549 BRD-K16189898 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92616 BRD-K16189898 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92645 BRD-K16189898 HT29 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
92689 BRD-K16189898 LNCAP 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92793 BRD-K16189898 MDAMB231 10 uM 3 h 0.0 0.0 0.0 -0.29 -0.96 0.44
95910 BRD-K16189898 YAPC 2.22 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
118411 BRD-K16189898 A375 3.33 uM 24 h 0.21 0.87 0.01 0.28 1.0 0.42
118478 BRD-K16189898 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118521 BRD-K16189898 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
118566 BRD-K16189898 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
118671 BRD-K16189898 PC3 10 uM 24 h 0.23 0.98 0.08 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).