CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01214
Pert ID:	BRD-A26384407
Compound Name:	chlorthalidone
Targets:	CA1\|CA12\|CA14\|CA4\|CA7\|SLC12A1\|SLC12A3
MoA:	carbonic anhydrase inhibitor
SMILES:	NS(=O)(=O)c1cc(ccc1Cl)C1(O)NC(=O)c2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5259	BRD-A26384407	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5718	BRD-A26384407	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
20831	BRD-A26384407	MCF??7.00	10 uM	24 h	-0.23	-0.96	0.1	0.0	0.0	0.0
21678	BRD-A26384407	VCAP	10 uM	6 h	0.0	0.0	0.0	0.23	0.82	0.1
42190	BRD-A26384407	ASC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.89	0.27
42534	BRD-A26384407	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.31	-1.05	0.69
43390	BRD-A26384407	NPC	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.77	0.09
43704	BRD-A26384407	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120876	BRD-A26384407	A375	0.37 uM	24 h	-0.21	-0.86	0.01	0.0	0.0	0.0
120975	BRD-A26384407	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121132	BRD-A26384407	YAPC	0.125 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.59
129123	BRD-A26384407	A549	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129173	BRD-A26384407	HELA	0.74 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
129205	BRD-A26384407	HT29	0.25 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.14
129234	BRD-A26384407	PC3	2.22 uM	24 h	0.29	1.2	0.43	0.21	0.75	0.04

Summary