CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01304
Pert ID:	BRD-K93034159
Compound Name:	cladribine
Targets:	ADA\|PNP\|POLA1\|POLE\|POLE2\|POLE3\|POLE4\|RRM1\|RRM2\|RRM2B
MoA:	adenosine deaminase inhibitor; ribonucleotide reductase inhibitor
SMILES:	Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
22888	BRD-K93034159	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
23193	BRD-K93034159	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
24242	BRD-K93034159	VCAP	10 uM	24 h	-0.24	-1.01	0.15	0.0	0.0	0.0
49913	BRD-K93034159	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50612	BRD-K93034159	HT29	10 uM	6 h	0.0	0.0	0.0	-0.26	-0.86	0.22
50701	BRD-K93034159	MCF??7.00	10 uM	24 h	-0.21	-0.88	0.03	0.0	0.0	0.0
52349	BRD-K93034159	PC3	10 uM	24 h	0.0	0.0	0.0	-0.43	-1.46	15.35
95385	BRD-K93034159	U2OS	10 uM	24 h	-0.26	-1.07	0.27	0.0	0.0	0.0
128230	BRD-K93034159	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128309	BRD-K93034159	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.55
128356	BRD-K93034159	THP1	1.11 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.26
135780	BRD-K93034159	A549	2.22 uM	24 h	-0.22	-0.91	0.05	0.2	0.71	0.02
135816	BRD-K93034159	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135855	BRD-K93034159	HEK293	0.25 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.23
135904	BRD-K93034159	HELA	2.22 uM	24 h	0.26	1.08	0.21	0.25	0.9	0.21
135993	BRD-K93034159	JURKAT	0.74 uM	24 h	-0.23	-0.95	0.09	-0.21	-0.71	0.03
136139	BRD-K93034159	YAPC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary