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CMap Candidate Details

Structure:
CMap ID: C01328
Pert ID: BRD-K34022604
Compound Name: clofarabine
Targets: POLA1|POLD1|POLE|RRM1|RRM2|RRM2B
MoA: ribonucleotide reductase inhibitor
SMILES: Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91198 BRD-K34022604 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
95376 BRD-K34022604 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.35 2.01
95474 BRD-K34022604 U2OS 10 uM 6 h 0.2 0.84 0.0 0.0 0.0 0.0
116007 BRD-K34022604 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116046 BRD-K34022604 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116088 BRD-K34022604 HCC515 0.37 uM 24 h 0.27 1.14 0.31 -0.43 -1.43 15.35
116131 BRD-K34022604 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120526 BRD-K34022604 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120624 BRD-K34022604 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120665 BRD-K34022604 HT29 1.11 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
120717 BRD-K34022604 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120783 BRD-K34022604 PC3 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
120826 BRD-K34022604 YAPC 0.125 uM 24 h -0.3 -1.25 0.71 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).