CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01338
Pert ID:	BRD-K52989797
Compound Name:	clomipramine
Targets:	GSTP1\|HTR2A\|HTR2B\|HTR2C\|SLC6A2\|SLC6A3\|SLC6A4
MoA:	serotonin transporter (SERT) inhibitor
SMILES:	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3228	BRD-K52989797	HCC515	10 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.19
3830	BRD-K52989797	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44987	BRD-K52989797	ASC	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.68
45280	BRD-K52989797	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.32	1.14	0.87
46103	BRD-K52989797	NPC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.33
46417	BRD-K52989797	PHH	10 uM	24 h	0.24	1.02	0.13	-0.2	-0.66	0.01
46742	BRD-K52989797	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
50019	BRD-K52989797	A549	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.08	0.81
96483	BRD-K52989797	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121603	BRD-K52989797	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129605	BRD-K52989797	HELA	0.25 uM	24 h	0.17	0.69	0.0	-0.23	-0.76	0.07
129636	BRD-K52989797	HT29	0.01 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.16
129661	BRD-K52989797	MCF??7.00	0.03 uM	24 h	-0.27	-1.13	0.41	0.0	0.0	0.0
129694	BRD-K52989797	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129728	BRD-K52989797	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary