CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01357
Pert ID:	BRD-K37289225
Compound Name:	clozapine
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|CALY\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HRH1\|HRH4\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR1F\|HTR2A\|HTR2B\|HTR2C\|HTR3A\|HTR5A\|HTR6\|HTR7
MoA:	dopamine receptor antagonist; serotonin receptor antagonist
SMILES:	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1450	BRD-K37289225	NPC	25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3190	BRD-K37289225	HCC515	10 uM	24 h	0.25	1.05	0.17	0.32	1.14	0.87
3783	BRD-K37289225	VCAP	10 uM	24 h	-0.31	-1.3	0.82	0.27	0.96	0.34
42357	BRD-K37289225	ASC	10 uM	24 h	0.17	0.71	0.0	0.0	0.0	0.0
42683	BRD-K37289225	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.38	1.33	1.72
43317	BRD-K37289225	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44113	BRD-K37289225	SKB	10 uM	24 h	0.25	1.05	0.18	0.0	0.0	0.0
91111	BRD-K37289225	HUH7	10 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
98377	BRD-K37289225	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99898	BRD-K37289225	U2OS	15 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
123268	BRD-K37289225	HA1E	0.04 uM	24 h	0.2	0.82	0.0	0.0	0.0	0.0
123299	BRD-K37289225	HELA	1.11 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
123328	BRD-K37289225	HT29	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123358	BRD-K37289225	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	-0.25	-0.86	0.2
123386	BRD-K37289225	MDAMB231	0.37 uM	24 h	0.0	0.0	0.0	-0.38	-1.3	1.57
123408	BRD-K37289225	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123477	BRD-K37289225	YAPC	10 uM	24 h	0.0	0.0	0.0	0.37	1.31	1.59
131520	BRD-K37289225	A375	0.08 uM	24 h	0.32	1.33	0.85	0.0	0.0	0.0
131536	BRD-K37289225	A549	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131606	BRD-K37289225	HEK293	0.01 uM	24 h	0.0	0.0	0.0	-0.22	-0.73	0.05
131699	BRD-K37289225	HUVEC	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131752	BRD-K37289225	JURKAT	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131923	BRD-K37289225	THP1	0.01 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.55

Summary