CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01370
Pert ID:	BRD-K00259736
Compound Name:	colchicine
Targets:	GLRA1\|GLRA2\|TUBA1A\|TUBA1B\|TUBA1C\|TUBA3C\|TUBA3D\|TUBA3E\|TUBA4A\|TUBB\|TUBB1\|TUBB2A\|TUBB2B\|TUBB3\|TUBB4A\|TUBB4B\|TUBB6\|TUBB8
MoA:	microtubule inhibitor
SMILES:	COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
99947	BRD-K00259736	U2OS	10 uM	6 h	0.0	0.0	0.0	-0.38	-1.28	1.45
122873	BRD-K00259736	HEK293	1.11 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61
122927	BRD-K00259736	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122998	BRD-K00259736	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123087	BRD-K00259736	MDAMB231	1.11 uM	24 h	0.26	1.1	0.24	-0.29	-0.97	0.45
123159	BRD-K00259736	THP1	10 uM	24 h	-0.28	-1.15	0.44	0.0	0.0	0.0
131196	BRD-K00259736	A375	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131225	BRD-K00259736	A549	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131268	BRD-K00259736	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.25	-0.85	0.19
131320	BRD-K00259736	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131335	BRD-K00259736	HUVEC	0.08 uM	24 h	0.24	1.01	0.12	0.0	0.0	0.0
131388	BRD-K00259736	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131422	BRD-K00259736	MCF??7.00	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131451	BRD-K00259736	PC3	2.22 uM	24 h	0.0	0.0	0.0	-0.29	-0.98	0.47
131479	BRD-K00259736	YAPC	0.25 uM	24 h	-0.2	-0.82	0.0	0.0	0.0	0.0

Summary