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CMap Candidate Details

Structure:
CMap ID: C01455
Pert ID: BRD-K90777969
Compound Name: cutamesine
Targets: SIGMAR1
MoA: sigma receptor agonist
SMILES: COc1ccc(CCN2CCN(CCCc3ccccc3)CC2)cc1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127739 BRD-K90777969 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127782 BRD-K90777969 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127862 BRD-K90777969 HEK293 3.33 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
127936 BRD-K90777969 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127989 BRD-K90777969 MCF10A 3.33 uM 24 h 0.22 0.9 0.02 -0.27 -0.92 0.33
128075 BRD-K90777969 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.99
135526 BRD-K90777969 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135563 BRD-K90777969 HELA 0.01 uM 24 h 0.29 1.21 0.45 0.0 0.0 0.0
135610 BRD-K90777969 HT29 0.08 uM 24 h -0.21 -0.89 0.04 0.0 0.0 0.0
135654 BRD-K90777969 JURKAT 0.03 uM 24 h -0.21 -0.89 0.04 -0.3 -1.0 0.52
135693 BRD-K90777969 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135717 BRD-K90777969 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).