CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01637
Pert ID:	BRD-K33211335
Compound Name:	dextromethorphan
Targets:	CHRNA2\|CHRNA3\|CHRNA4\|CHRNA7\|CHRNB2\|CHRNB4\|CYBA\|CYBB\|GRIN3A\|NCF1\|NCF2\|NCF4\|OPRD1\|OPRK1\|OPRM1\|PGRMC1\|RAC1\|RAC2\|SIGMAR1\|SLC6A2\|SLC6A4
MoA:	glutamate receptor antagonist; sigma receptor agonist
SMILES:	COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4563	BRD-K33211335	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25357	BRD-K33211335	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.81
39672	BRD-K33211335	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39986	BRD-K33211335	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40791	BRD-K33211335	NEU	10 uM	24 h	0.23	0.94	0.06	0.0	0.0	0.0
41093	BRD-K33211335	NPC	10 uM	24 h	0.0	0.0	0.0	-0.21	-0.72	0.04
41426	BRD-K33211335	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91237	BRD-K33211335	HUH7	12.5 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
99852	BRD-K33211335	U2OS	6.66 uM	6 h	-0.28	-1.17	0.48	0.0	0.0	0.0
120522	BRD-K33211335	A375	1.11 uM	24 h	0.0	0.0	0.0	0.28	0.99	0.41
120556	BRD-K33211335	A549	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120596	BRD-K33211335	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.13	0.97
120620	BRD-K33211335	HELA	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120657	BRD-K33211335	HT29	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120709	BRD-K33211335	JURKAT	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120754	BRD-K33211335	MCF??7.00	0.04 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.13
120777	BRD-K33211335	PC3	10 uM	24 h	0.0	0.0	0.0	0.34	1.2	1.07
120817	BRD-K33211335	YAPC	10 uM	24 h	-0.32	-1.31	0.82	-0.32	-1.09	0.82
136414	BRD-K33211335	SHSY5Y	0.125 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.81

Summary