CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01652
Pert ID:	BRD-K73109821
Compound Name:	diazoxide
Targets:	ATP1A1\|CA1\|CA2\|KCNJ11\|KCNJ8\|KCNMA1\|SLC12A3
MoA:	potassium channel activator
SMILES:	CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3255	BRD-K73109821	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25414	BRD-K73109821	VCAP	10 uM	24 h	0.0	0.0	0.0	0.24	0.84	0.12
45015	BRD-K73109821	ASC	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.06	0.73
45308	BRD-K73109821	HEPG2	10 uM	6 h	-0.31	-1.29	0.77	0.0	0.0	0.0
46130	BRD-K73109821	NPC	10 uM	24 h	0.21	0.89	0.02	-0.25	-0.83	0.15
46444	BRD-K73109821	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46769	BRD-K73109821	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91104	BRD-K73109821	HUH7	15 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
99440	BRD-K73109821	U2OS	20 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
126661	BRD-K73109821	A549	10 uM	24 h	0.0	0.0	0.0	0.34	1.2	1.06
126682	BRD-K73109821	HA1E	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126731	BRD-K73109821	HELA	10 uM	24 h	0.24	1.02	0.13	0.0	0.0	0.0
126756	BRD-K73109821	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.24	0.84	0.12
126863	BRD-K73109821	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126905	BRD-K73109821	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126978	BRD-K73109821	THP1	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134688	BRD-K73109821	A375	0.74 uM	24 h	-0.24	-0.99	0.13	0.0	0.0	0.0
134782	BRD-K73109821	HEK293	0.03 uM	24 h	0.29	1.22	0.48	-0.35	-1.19	1.16
134892	BRD-K73109821	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134914	BRD-K73109821	JURKAT	0.01 uM	24 h	-0.26	-1.09	0.32	0.0	0.0	0.0
134936	BRD-K73109821	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134978	BRD-K73109821	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135008	BRD-K73109821	YAPC	0.01 uM	24 h	0.21	0.87	0.01	-0.27	-0.9	0.29

Summary