CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01681
Pert ID:	BRD-K22031190
Compound Name:	diflunisal
Targets:	PTGS1\|PTGS2
MoA:	prostanoid receptor antagonist
SMILES:	OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5762	BRD-K22031190	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.36	-1.22	1.25
5894	BRD-K22031190	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42325	BRD-K22031190	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
43516	BRD-K22031190	NPC	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
43814	BRD-K22031190	PHH	10 uM	24 h	0.22	0.93	0.05	-0.24	-0.8	0.11
51136	BRD-K22031190	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
91243	BRD-K22031190	HUH7	12.5 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
120861	BRD-K22031190	A375	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120886	BRD-K22031190	A549	10 uM	24 h	-0.19	-0.78	0.0	0.0	0.0	0.0
120947	BRD-K22031190	HEK293	0.125 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.23
121015	BRD-K22031190	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121039	BRD-K22031190	MCF??7.00	10 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
121105	BRD-K22031190	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129132	BRD-K22031190	HA1E	2.22 uM	24 h	-0.21	-0.87	0.02	0.0	0.0	0.0
129150	BRD-K22031190	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129219	BRD-K22031190	PC3	0.74 uM	24 h	0.22	0.94	0.06	-0.28	-0.96	0.42

Summary