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CMap Candidate Details

Structure:
CMap ID: C01692
Pert ID: BRD-K72166146
Compound Name: dihydroergotamine
Targets: ADRA2A|DRD2|HTR1B|HTR1D|HTR1E|HTR1F|HTR2B|HTR7
MoA: serotonin receptor agonist
SMILES: CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N[C@]1(C)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5799 BRD-K72166146 HCC515 10 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.19
6358 BRD-K72166146 VCAP 10 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
42460 BRD-K72166146 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42771 BRD-K72166146 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43638 BRD-K72166146 NPC 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.02
43937 BRD-K72166146 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44192 BRD-K72166146 SKB 10 uM 24 h -0.31 -1.29 0.77 0.0 0.0 0.0
126638 BRD-K72166146 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126751 BRD-K72166146 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126788 BRD-K72166146 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126815 BRD-K72166146 MCF10A 0.04 uM 24 h 0.21 0.86 0.01 0.27 0.97 0.36
126858 BRD-K72166146 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126902 BRD-K72166146 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
126971 BRD-K72166146 THP1 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
134710 BRD-K72166146 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134744 BRD-K72166146 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134779 BRD-K72166146 HEK293 0.74 uM 24 h -0.31 -1.3 0.81 0.0 0.0 0.0
134807 BRD-K72166146 HELA 0.01 uM 24 h 0.28 1.17 0.36 0.22 0.79 0.07
134885 BRD-K72166146 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.7
134974 BRD-K72166146 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135002 BRD-K72166146 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).