CMap Candidate Details
Structure:
| CMap ID: | C01713 |
| Pert ID: | BRD-K31111078 |
| Compound Name: | dimethyl-fumarate |
| Targets: | KEAP1 |
| MoA: | nuclear factor erythroid derived; like (NRF2) activator |
| SMILES: | COC(=O)\C=C\C(=O)OC |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 120507 | BRD-K31111078 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.27 | 0.95 | 0.31 |
| 120539 | BRD-K31111078 | A549 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120585 | BRD-K31111078 | HA1E | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120640 | BRD-K31111078 | HT29 | 10 uM | 24 h | 0.15 | 0.65 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120690 | BRD-K31111078 | JURKAT | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120744 | BRD-K31111078 | MCF??7.00 | 10 uM | 24 h | 0.21 | 0.87 | 0.01 | -0.26 | -0.88 | 0.24 |
| 120764 | BRD-K31111078 | PC3 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120796 | BRD-K31111078 | YAPC | 0.04 uM | 24 h | -0.21 | -0.89 | 0.04 | -0.25 | -0.85 | 0.2 |
| 129018 | BRD-K31111078 | HELA | 0.25 uM | 24 h | -0.25 | -1.05 | 0.23 | 0.38 | 1.33 | 1.72 |