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CMap Candidate Details

Structure:
CMap ID: C01719
Pert ID: BRD-K13662825
Compound Name: dinaciclib
Targets: CDK1|CDK2|CDK5|CDK9
MoA: CDK inhibitor
SMILES: CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
513 BRD-K13662825 BJAB 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
546 BRD-K13662825 HBL1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
582 BRD-K13662825 K562 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
651 BRD-K13662825 KMS34 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
696 BRD-K13662825 MINO 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
744 BRD-K13662825 NALM6 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
774 BRD-K13662825 OCILY19 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
841 BRD-K13662825 OCILY3 0.01 uM 4 h 0.0 0.0 0.0 0.26 0.93 0.27
886 BRD-K13662825 SKMEL5 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
927 BRD-K13662825 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
946 BRD-K13662825 TMD8 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92924 BRD-K13662825 ASC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92986 BRD-K13662825 CD34 0.12 uM 24 h 0.29 1.23 0.5 0.0 0.0 0.0
93163 BRD-K13662825 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93212 BRD-K13662825 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93413 BRD-K13662825 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93477 BRD-K13662825 SKL 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95321 BRD-K13662825 A549 1.11 uM 48 h -0.28 -1.18 0.51 -0.34 -1.16 1.1
95364 BRD-K13662825 MCF??7.00 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95433 BRD-K13662825 U2OS 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
122256 BRD-K13662825 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122318 BRD-K13662825 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122331 BRD-K13662825 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122364 BRD-K13662825 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122421 BRD-K13662825 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
122441 BRD-K13662825 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
130594 BRD-K13662825 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130711 BRD-K13662825 HT29 0.08 uM 24 h 0.28 1.16 0.34 0.3 1.06 0.59
130840 BRD-K13662825 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).