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CMap Candidate Details

Structure:
CMap ID: C01738
Pert ID: BRD-K64838454
Compound Name: dipraglurant
Targets: GRM5
MoA: glutamate receptor negative allosteric modulator
SMILES: Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124940 BRD-K64838454 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124972 BRD-K64838454 A549 10 uM 24 h 0.2 0.85 0.01 -0.34 -1.14 1.04
125003 BRD-K64838454 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125170 BRD-K64838454 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.63
133057 BRD-K64838454 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133093 BRD-K64838454 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133122 BRD-K64838454 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133164 BRD-K64838454 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133202 BRD-K64838454 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133230 BRD-K64838454 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133264 BRD-K64838454 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133296 BRD-K64838454 PC3 0.01 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
133318 BRD-K64838454 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.64
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).