CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01740
Pert ID:	BRD-K86301799
Compound Name:	dipyridamole
Targets:	ADA\|PDE10A\|PDE1A\|PDE1B\|PDE1C\|PDE2A\|PDE3A\|PDE3B\|PDE4A\|PDE4B\|PDE4C\|PDE4D\|PDE5A\|PDE6A\|PDE6B\|PDE6C\|PDE6D\|PDE6G\|PDE6H\|PDE7A\|PDE7B\|PDE8A\|PDE8B\|PDE9A\|SLC29A1
MoA:	phosphodiesterase inhibitor
SMILES:	OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5691	BRD-K86301799	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.76
6597	BRD-K86301799	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42488	BRD-K86301799	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42798	BRD-K86301799	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
43663	BRD-K86301799	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
43963	BRD-K86301799	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44215	BRD-K86301799	SKB	10 uM	24 h	0.0	0.0	0.0	0.25	0.89	0.2
50069	BRD-K86301799	A549	10 uM	6 h	0.0	0.0	0.0	-0.36	-1.21	1.24
91151	BRD-K86301799	HUH7	6.66 uM	72 h	-0.27	-1.13	0.4	-0.23	-0.78	0.1
96988	BRD-K86301799	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124333	BRD-K86301799	HEK293	10 uM	24 h	0.37	1.53	1.45	0.0	0.0	0.0
124372	BRD-K86301799	HELA	0.04 uM	24 h	0.0	0.0	0.0	0.36	1.27	1.34
124442	BRD-K86301799	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124503	BRD-K86301799	MDAMB231	10 uM	24 h	-0.26	-1.07	0.27	-0.23	-0.78	0.09
124565	BRD-K86301799	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132403	BRD-K86301799	HA1E	0.25 uM	24 h	0.0	0.0	0.0	-0.43	-1.43	15.35
132476	BRD-K86301799	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132512	BRD-K86301799	MCF10A	0.74 uM	24 h	0.3	1.24	0.53	0.22	0.78	0.06
132541	BRD-K86301799	MCF??7.00	0.01 uM	24 h	-0.25	-1.06	0.26	0.0	0.0	0.0
132579	BRD-K86301799	PC3	0.01 uM	24 h	0.2	0.83	0.0	0.0	0.0	0.0
132631	BRD-K86301799	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary