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CMap Candidate Details

Structure:
CMap ID: C01760
Pert ID: BRD-K54936858
Compound Name: DMP-777
Targets: MPO
MoA: elastase inhibitor
SMILES: CCC[C@@H](NC(=O)N1[C@@H](Oc2ccc(cc2)C(=O)N2CCN(C)CC2)C(CC)(CC)C1=O)c1ccc2OCOc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124278 BRD-K54936858 A375 10 uM 24 h -0.24 -0.99 0.14 -0.29 -0.96 0.44
124290 BRD-K54936858 A549 10 uM 24 h -0.36 -1.52 1.43 0.0 0.0 0.0
124361 BRD-K54936858 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124429 BRD-K54936858 JURKAT 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
124554 BRD-K54936858 YAPC 10 uM 24 h 0.27 1.12 0.27 0.27 0.95 0.32
132395 BRD-K54936858 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
132430 BRD-K54936858 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132469 BRD-K54936858 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132501 BRD-K54936858 MCF10A 0.03 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
132530 BRD-K54936858 MCF??7.00 2.22 uM 24 h 0.27 1.14 0.32 0.31 1.11 0.72
132558 BRD-K54936858 MDAMB231 0.03 uM 24 h 0.2 0.85 0.0 -0.15 -0.5 0.0
132575 BRD-K54936858 PC3 0.08 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
132617 BRD-K54936858 THP1 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).