CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01775
Pert ID:	BRD-K78567475
Compound Name:	dolastatin-10
Targets:	TUBB
MoA:	tubulin polymerization inhibitor
SMILES:	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
127033	BRD-K78567475	A375	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
127053	BRD-K78567475	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127117	BRD-K78567475	HELA	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.09	0.82
127152	BRD-K78567475	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127255	BRD-K78567475	PC3	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
135060	BRD-K78567475	A549	0.25 uM	24 h	-0.25	-1.03	0.19	-0.38	-1.29	1.53
135117	BRD-K78567475	HEK293	0.08 uM	24 h	0.0	0.0	0.0	-0.34	-1.16	1.09
135187	BRD-K78567475	JURKAT	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135219	BRD-K78567475	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135237	BRD-K78567475	MCF??7.00	0.03 uM	24 h	-0.17	-0.71	0.0	0.0	0.0	0.0
135285	BRD-K78567475	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.07
135315	BRD-K78567475	THP1	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135333	BRD-K78567475	YAPC	0.25 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.12

Summary