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CMap Candidate Details

Structure:
CMap ID: C00178
Pert ID: BRD-K11267252
Compound Name: alectinib
Targets: ALK|MET
MoA: ALK tyrosine kinase receptor inhibitor
SMILES: CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1189 BRD-K11267252 PC3 10 uM 24 h 0.25 1.02 0.13 0.0 0.0 0.0
1386 BRD-K11267252 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.89
94450 BRD-K11267252 A549 10 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
94485 BRD-K11267252 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94554 BRD-K11267252 CD34 10 uM 24 h 0.34 1.41 1.03 0.0 0.0 0.0
94601 BRD-K11267252 HCC515 3.33 uM 24 h -0.29 -1.19 0.55 0.0 0.0 0.0
94645 BRD-K11267252 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94749 BRD-K11267252 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94841 BRD-K11267252 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
94894 BRD-K11267252 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.36
94939 BRD-K11267252 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.19 0.67 0.01
94978 BRD-K11267252 MCF??7.00 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
95020 BRD-K11267252 NEU 0.12 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
95079 BRD-K11267252 NPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.84
95167 BRD-K11267252 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95211 BRD-K11267252 SKL 0.04 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
95277 BRD-K11267252 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121172 BRD-K11267252 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121241 BRD-K11267252 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
121259 BRD-K11267252 HELA 3.33 uM 24 h 0.18 0.77 0.0 -0.23 -0.78 0.09
129320 BRD-K11267252 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
129393 BRD-K11267252 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).